If the liquid is out of stock
In busy flu seasons, some pharmacies run out of oseltamivir. In January 2026, the American Society of Health-System Pharmacists listed shortages of some oseltamivir capsules and powders, which federal agencies attributed to local stockouts from high demand.[4]
The FDA label describes two backup options when the liquid is not available:[3]
- Opened capsules. The contents of the right-strength capsule (30, 45, or 75 mg) can be mixed with a small amount of a sweet liquid such as chocolate syrup (regular or sugar-free), corn syrup, caramel topping, or light brown sugar dissolved in water.
- A pharmacy-made liquid. When neither the liquid nor the right capsule strength is available, a pharmacist can prepare an emergency liquid from 75 mg capsules.
Ask the pharmacist which option fits your child's prescription, and have them show you how to measure it. Do not split or guess at an adult capsule on your own. Calling two or three pharmacies before you drive is often faster.
What about Xofluza?
Baloxavir (Xofluza) is a single-dose flu medicine approved for children 5 and older; it is not approved under 5.[5] A generic version was approved in June 2026 for the same ages.[6] The liquid form of baloxavir is not currently available in the U.S., so a child needs to be able to swallow tablets.[1]
Side effects and behavior changes
The most common side effects of oseltamivir are nausea and vomiting. Giving it with food can make it easier to tolerate.[3]
The label notes rare reports, mainly in children, of sudden confusion or unusual behavior. Flu itself can cause these symptoms, and the medicine's role has not been established. Watch your child closely and call their clinician if their behavior changes.[3]
A 2025 study of children ages 5 to 17 enrolled in Tennessee Medicaid from 2016 to 2020 found that children with flu who were treated with oseltamivir had a lower risk of serious neuropsychiatric events than children with flu who were not treated. The authors concluded the findings should inform caregivers and clinicians about the medicine's safety.[7] More on Tamiflu side effects.
Fever and pain relief
Never give aspirin or products that contain aspirin to anyone younger than 19 with flu. It can cause Reye syndrome, a rare but serious illness of the liver and brain.[8] Ask your pharmacist which fever reducer and dose fit your child's age and weight.
Warning signs in children
Get emergency care for any of these:[9]
- Fast breathing or trouble breathing
- Bluish lips or face
- Ribs pulling in with each breath
- Chest pain
- Severe muscle pain (the child refuses to walk)
- Dehydration: no urine for 8 hours, dry mouth, no tears when crying
- Not alert or interacting when awake
- Seizures
- Fever above 104°F (40°C) not controlled by fever-reducing medicine
- In children younger than 12 weeks, any fever
- Fever or cough that improves but then returns or gets worse
- Worsening of chronic medical conditions
Warning signs for adults and children.
Your next step
If your child has flu symptoms and is under 5, has a long-term condition, or seems to be getting worse, call their pediatrician today and ask whether an antiviral is right for them.